31/08/2025 – Haem and Vascular

Question Easy:
A 32-year-old woman presents with fatigue and pallor. Her full blood count shows microcytic, hypochromic anaemia. What is the most likely cause of her anaemia? 🤔
A) Iron deficiency anaemia
B) Sickle cell disease
C) Folate deficiency
D) Vitamin B12 deficiency
E) Thalassaemia

Explanations & Answers:

Question Easy Answer: A) Iron deficiency anaemia

Question Easy Explanation:
Iron deficiency anaemia is the most common cause of microcytic, hypochromic anaemia, particularly in women of childbearing age due to menstrual losses. NICE guidelines recommend checking serum ferritin to confirm iron deficiency.

Question Medium:
A 65-year-old man presents with a painful, swollen calf after a long-haul flight. A Doppler ultrasound confirms a deep vein thrombosis (DVT). According to NICE guidelines, what is the first-line treatment to initiate? ✈️🦵
A) Warfarin
B) Aspirin
C) Low molecular weight heparin (LMWH)
D) Thrombolysis
E) Surgical thrombectomy

Question Medium Answer: C) Low molecular weight heparin (LMWH)

Question Medium Explanation:
NICE guidelines recommend low molecular weight heparin (such as enoxaparin) as the first-line treatment for acute DVT. It is typically used for the initial anticoagulation period, transitioning to oral anticoagulants like warfarin subsequently.

Question Hard:
A 52-year-old woman with a history of chronic kidney disease presents with fatigue and shortness of breath. Her haemoglobin levels are low, consistent with normocytic anaemia. What is the most appropriate treatment for her anaemia?
A) Iron supplements
B) Erythropoiesis-stimulating agents (ESAs)
C) Blood transfusion
D) Vitamin B12 injections
E) Folate supplements

Question Hard Answer: B) Erythropoiesis-stimulating agents (ESAs)

Question Hard Explanation:
In patients with anaemia of chronic kidney disease, erythropoiesis-stimulating agents (such as erythropoietin) are used to stimulate red blood cell production. NICE guidelines outline their use to manage anaemia in CKD, especially when iron stores are adequate.

Medical fact of the day:
Did you know that deep vein thrombosis (DVT) is more common in the left leg than the right? This is due to the anatomical compression of the left iliac vein by the right iliac artery, which is a phenomenon known as May-Thurner syndrome. 🌍🦵

Quote of the day:
“In the marathon of healthcare, every patient you aid becomes your stride forward—a testament to endurance, compassion, and an unwavering journey towards healing.” ✨